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Fig. 9 | Molecular Medicine

Fig. 9

From: Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis

Fig. 9

Effect and potential mechanism of ASM on T2DOP. Sixty SD rats were divided into four groups (n = 15). A Determination of iron ion levels in serum. B MDA measurement in serum. C Determination of ASM activity in serum. D Detection of ceramide in serum. E IHC for ASM, Beclin 1, LC3 and GPX4 in four groups of rats. Scale bar = 100 μm. ****P < 0.0001

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Molecular Medicine

ISSN: 1528-3658