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Fig. 2 | Molecular Medicine

Fig. 2

From: Interaction between N6-methyladenosine modification and the tumor microenvironment in colorectal cancer

Fig. 2

m6A modifications interact with the CRC metabolic microenvironment. m6A “writers” METTL3 promotes CRC proliferation by targeting LDHA and PTTG3P to regulate glycolysis. KIAA1429 promotes CRC proliferation by increasing the expression of HK2. METTL14 promotes CRC progression by inhibiting miR-149-3p. m6A “readers”, IPM2 targets ZFAS1 to mediate mitochondrial metabolism and inhibit CRC proliferation. YTHDF1 promotes CRC chemoresistance by mediating glutamate metabolism. YTHDF2 targets DEGS2 to regulate CRC lipid metabolism and inhibit CRC progression. The role of m6A “erasers” in the metabolic microenvironment in which CRC resides is still unclear

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Molecular Medicine

ISSN: 1528-3658