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Fig. 4 | Molecular Medicine

Fig. 4

From: Interaction between N6-methyladenosine modification and the tumor microenvironment in colorectal cancer

Fig. 4

m6A modifications interact with the CRC inflammatory microenvironment. METTL3 promotes the formation of the inflammatory microenvironment and CRC proliferation by inhibiting SOCS2. Additionally, METTL3 promotes M1-type macrophage polarization and inhibits M2-type macrophage by promoting STAT1 expression. The m6A methylated EphA2/VEGFA promotes angiogenesis in CRC by targeting the PI3K/AKT inflammatory signaling pathway. The functions of m6A “erasers” in the inflammatory microenvironment of CRC are still unclear

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Molecular Medicine

ISSN: 1528-3658