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Fig. 5 | Molecular Medicine

Fig. 5

From: Interaction between N6-methyladenosine modification and the tumor microenvironment in colorectal cancer

Fig. 5

m6A modifications interact with the immune microenvironment of CRC. In m6A “writers”, METTL3 promotes infiltration of MDSCs and suppresses CD8+ T cells by targeting BHLHE41. METTL3 promotes the stem cell-like phenotype of CRC by targeting Sec62. METTL3 promotes CRC progression by targeting NCALD and TCF7L2. METTL14 represses the proliferation of CRC by targeting XIST expression. In m6A “Readers”, YTHDF1 inhibits DCs antigen presentation and CD8+T cells activation. YTHDF3 promotes the translation of drug-resistance genes by recruiting eLF2AK2. In m6A “Erasers”, inhibition of FTO deregulates PD-L1 expression and CRC progression. ALKBH5 inhibits the infiltration of Tregs and MDSCs and the progression of CRC by targeting Mct4/Slc16a3

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Molecular Medicine

ISSN: 1528-3658