Fig. 3

Screening of differentially expressed genes in serum-Exos from T2DM mice by transcriptome sequencing analysis. A The expression heat map of the top 50 differentially expressed genes with the smallest P. value, blue to red, represents increasing expression values; B the expression box plot of MALAT1 in serum-Exos from T2DM mice and blank mice (blank: n = 10, T2DM: n = 10); C the expression box plot of miR-382-3p in serum-Exos from T2DM mice and blank mice (blank: n = 10, T2DM: n = 10); D detection of MALAT1 and miR-382-3p expression in hippocampal neurons of T2DM mice by RT-qPCR (P < 0.05 compared with the control group); E Detection of MALAT1 and miR-382-3p expression levels in brain hippocampal tissue in mouse model by RT-qPCR (n = 10, *P < 0.05 compared with the blank group); n = 10, *P < 0.05 compared with the blank + Exos group, ^#P < 0.05 compared with the HF + Exos group. All cell experiments were performed three times