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Fig. 7 | Molecular Medicine

Fig. 7

From: Aerobic exercise improves cognitive impairment in mice with type 2 diabetes by regulating the MALAT1/miR-382-3p/BDNF signaling pathway in serum-exosomes

Fig. 7

Effects of silent MALAT1 on hippocampal neuron apoptosis. A RT-qPCR detection of the efficiency of MALAT1 silencing (*P < 0.05 compared with the sh-NC group); B RT-qPCR detection of MALAT1 expression in hippocampal neurons of each group; C Western blot detection of INSR expression in hippocampal neurons; D CCK-8 detection of hippocampal neuron activity in each group; E EdU experiment was used to detect apoptosis of hippocampal neurons in each group; F flow cytometry was used to detect apoptosis of hippocampal neurons in each group; G–I Western blot detection of PI3K, AKT, p-AKT, Ras, Erk1/2, p- Erk1/2 expression; H Western blot detection of Cleaved Caspase-3, Caspase-3, Bax, BCL-2 expression; I Western blot detection of SNAP-25, VGluT-1 expression in hippocampal neurons; *P < 0.05 compared with the HG + Exos + sh-NC group; all cell experiments were repeated three times

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Molecular Medicine

ISSN: 1528-3658