Fig. 6

Resveratrol ameliorates intestinal I/R injury in a mouse I/R model. (a) Representative HE staining images of intestinal mucosa after drinking resveratrol (30 mg/L) for 2 weeks (n = 8). Scale bars: 200 μm. (b) Chiu’s score of intestinal tissue injury in Sirt3^+/+ and Sirt3^−/− mice treated with resveratrol and/or I/R (n = 8). (c) Representative Western blots of ZO-1 and Occludin in Sirt3^+/+ and Sirt3^−/− mice treated with resveratrol and/or I/R (n = 8). (d) Representative Western blots of GPX4, FTH1 and ACSL4 levels in Sirt3^+/+ and Sirt3^−/− mice treated with resveratrol and/or I/R (n = 8). (e) Quantitation of ZO-1 and Occludin in Sirt3^+/+ and Sirt3^−/− mice treated with resveratrol and/or I/R (n = 8). (f) Quantitation of GPX4, FTH1 and ACSL4 levels in Sirt3^+/+ and Sirt3^−/− mice treated with resveratrol and/or I/R (n = 8). Data are presented as the mean ± SD. All experiments were repeated in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001. Kruskal-Wallis H test (b), two-way ANOVA (e, f)