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Fig. 8 | Molecular Medicine

Fig. 8

From: Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles

Fig. 8

Inhibition of ROCK partially reverses prostatic hyperplasia of the BPH rat model. A The simple schematic model of in vivo experiments. B The rat urogenital tissues from NC, T-BPH, and T-BPH + Y rats. (1) ventral prostate, (2) seminal vesicle, and (3) bladder. (C) Representative H&E staining of NC, T-BPH, and T-BPH + Y rat prostates. D Representative Immunohistochemical staining of RhoA and β-catenin for NC, T-BPH, and T-BPH + Y rat prostates. E Immunoblot assay of proteins in relation to RhoA-ROCK-β-catenin signal axis system (RhoA, ROCK1, ROCK2, β-catenin, C-MYC, Survivin, Snail and CyclinD1) and related phenotypes in NC, T-BPH, and T-BPH + Y rat prostates. F The simple schematic model proposed for the central roles of RhoA-ROCK-β-catenin signal axis system in the development of BPH. Data were expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001

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Molecular Medicine

ISSN: 1528-3658