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Fig. 6 | Molecular Medicine

Fig. 6

From: Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation

Fig. 6

Vitexin treatment attenuates UIR-induced CKD in mice. (A) Sirius red staining of kidneys and relative fibrotic areas. (B) IHC staining of collagen I and the relative MFI of collagen I are shown on the right. (C) The protein expression of Fibronectin, α-SMA and E-cadherin in renal tissues was detected by WB and semiquantified. (D) Representative electron microscopy images and quantification of damaged mitochondria in renal tissues (scale bar: 1 μm). (E) The protein levels of NRF2, MPO and GPX4 in the kidneys of UIR mice with or without vitexin treatment were analyzed by WB, and the densitometry results are shown. The results are shown as the mean ± S.D. of 3 or 6 mice in each group; ****P < 0·0001, ***P < 0·001, **P < 0·01 (one-way ANOVA).

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Molecular Medicine

ISSN: 1528-3658