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Fig. 5 | Molecular Medicine

Fig. 5

From: Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARγ transcriptional network in mice fed high fat diet

Fig. 5

Swimming exercise inhibits PPARγ signaling and recruitment to PPARγ target gene promoters. A The mRNA level and B-C protein levels of PPARγ in liver of the indicated groups and corresponding quantitative analysis, all experiments were repeated at least 3 times independently. D the mRNA levels of PPARγ target genes related to fatty acid uptake and synthesis in liver samples from the indicated group mice. E ChIP assays were performed on the CD36, SCD1 and PLIN2 promoters in liver extracted from the indicated group mice (n = 3 per group). Promoter occupancy by PPARγ was analyzed. Data is presented as mean ± SD. n = 6. A two-tailed Student’s t-test was performed for comparison of results between indicated groups. *p < 0.05, **p < 0.01 between groups

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Molecular Medicine

ISSN: 1528-3658