Table 2 Diagnostic performance of the tests for diagnosis of pulmonary tuberculosis
| Â | Sensitivity % (95%CI; n/N) | Specificity % (95%CI; n/N) | PPV % | NPV % |
|---|---|---|---|---|
Total | Â | Â | Â | Â |
MeltPro | 69.0 (65.8–72.1; 604/875) | 97.1 (94.8–98.4; 396/408) | 98.1 | 59.4 |
Xpert | 72.7 (69.6–75.6; 636/875) | 98.0 (96.0–99.1; 400/408) | 98.8 | 62.6 |
MGIT | 58.1 (54.7–61.3; 508/875) | 100 (98.8–100.0; 408/408) | 100 | 52.6 |
Smear | 38.5 (35.3–41.8; 337/875) | 88.2 (84.6–91.1; 360/408) | 87.5 | 40.1 |
Smear positive | Â | Â | Â | Â |
MeltPro | 97.9 (95.6–99.1; 330/337) | 91.7 (79.1–97.3; 44/48) | 98.8 | 86.3 |
Xpert | 98.5 (96.4–99.5; 332/337) | 97.9 (87.5–99.9; 47/48) | 99.7 | 90.4 |
MGIT | 97.9 (95.6–99.1; 330/337) | 100 (90.8–100.0; 48/48) | 100 | 87.3 |
Smear negative | Â | Â | Â | Â |
MeltPro | 50.9 (44.6–55.2; 274/538) | 97.8 (95.5–99.0; 352/360) | 97.2 | 57.1 |
Xpert | 56.5 (52.2–60.7; 304/538) | 98.1 (95.9–99.2; 353/360) | 97.7 | 60.1 |
MGIT | 33.1 (29.2–37.3; 178/538) | 100 (98.7–100.0; 360/360) | 100 | 50.0 |
Sputum | Â | Â | Â | Â |
MeltPro | 65.4 (61.7–69.1; 430/657) | 97.1 (94.4–98.6; 303/312) | 97.9 | 57.2 |
Xpert | 70.3 (66.6–73.8; 462/657) | 98.4 (96.1–99.4; 307/312) | 98.9 | 61.2 |
MGIT | 54.9 (51.1–58.8; 361/657) | 100 (98.5–100.0; 312/312) | 100 | 51.3 |
BALF | Â | Â | Â | Â |
MeltPro | 81.3 (74.8–86.5; 152/187) | 96.2 (88.4–99.0; 75/78) | 98.1 | 68.2 |
Xpert | 80.7 (74.2–86.0; 151/187) | 97.4 (90.2–99.6; 76/78) | 98.7 | 67.9 |
MGIT | 69.5 (62.3–75.9; 130/187) | 100 (94.2–100.0; 78/78) | 100 | 57.8 |
Pulmonary puncture fluid | Â | Â | Â | Â |
MeltPro | 71.0 (51.8–85.1; 22/31) | 100 (78.1–100.1; 18/18) | 100 | 66.7 |
Xpert | 74.2 (55.1–87.5; 23/31) | 94.4 (70.6–99.7; 17/18) | 95.8 | 68.0 |
MGIT | 54.8 (36.3–72.2; 17/31) | 100 (78.1–100.1; 18/18) | 100 | 56.3 |