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Table 4 Diagnostic performance of MeltPro TB for detection of resistance to INH, EMB, STR, and FQ*

From: Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection

Drugs

Sensitivity % (95%CI; n/N)

Specificity % (95%CI; n/N)

PPV %

NPV %

INH

96.4 (90.4–98.8; 106/110)

96.0 (92.8–97.9; 266/277)

90.6

98.5

EMB

89.1 (75.6–95.9; 41/46)

96.0 (93.3–97.7; 339/353)

74.5

98.5

STR

97.5 (90.3–99.6; 77/79)

95.2 (92.0–97.2; 297/312)

83.7

99.3

FQ

90.3 (79.5–96.0; 56/62)

99.4 (97.8–99.9; 354/356)

96.6

98.3

  1. *MYCOTB as reference standards; INH isoniazid, EMB ethambutol, STR streptomycin, FQ fluoroquinolone, PPV positive predictive value, NPV negative predictive value
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Molecular Medicine

ISSN: 1528-3658