Fig. 6From: CRTC2 activates the epithelial–mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathwayCRTC2 modulates EMT via CREB-Smad2/3 pathway in DKD. CRTC2, as a co-activator of CREB, enters into nucleus and binds to CREB, then CREB promotes the Smads complex to identify the target genes to induce EMT processBack to article page