Fig. 6

Nicotinic acetylcholine receptors are not required for galantamine-mediated amelioration of acute pancreatitis. Galantamine administration significantly reduces serum amylase (A) and elevates serum IL-10 (B) in α7nAChR KO and WT mice. C, D Pre-treatment with nicotinic antagonists, mecamylamine (1 mg/kg-bw) or methyllycaconitine (1 mg/kg-bw) does not alter galantamine-mediated suppression of serum amylase. Data are represented as individual mouse data points with mean ± SEM. Unpaired t-test, *p < 0.05, **p < 0.01, ns = not significant. n = 10–11