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Fig. 10 | Molecular Medicine

Fig. 10

From: Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer

Fig. 10

Exosomal circCOL1A1 promotes tumor growth and angiogenesis in vivo. (A) Photographs of xenograft tumors. (B) Quantitative analysis of tumor volume. (C) Quantitative analysis of tumor weight. (D) The immunoreactivities of Ki-67, E-cadherin, N-cadherin, VEGFR and CD31were analyzed by IHC. Scale bar, 50 μm. (E) The circCOL1A1 levels in xenograft tumors were determined by qRT-PCR. (F) The protein levels of EIF4A3, p-Smad2, Smad2, p-Smad3, Smad3, and VEGFR in xenograft tumors were detected by western blot. *, P < 0.05, **, P < 0.01, ***, P < 0.001

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Molecular Medicine

ISSN: 1528-3658