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Fig. 5 | Molecular Medicine

Fig. 5

From: Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer

Fig. 5

Exosomal circCOL1A1 promotes angiogenesis of HUVECs via recruiting EIF4A3. HUVECs were transfected with pcDNA3.1-NC or pcDNA3.1-EIF4A3, followed by treatment with CRC cell-derived exosomes. (A) The circCOL1A1 level in HUVECs was determined by qRT-PCR. (B) The protein level of EIF4A3 in HUVECs was detected by western blot. (C) Cell migration was assessed by wound healing assay. (D) Cell proliferation was monitored by CCK-8 assay. (E) The in vitro angiogenesis was detected by tube formation assay. *, P < 0.05, **, P < 0.01, ***, P < 0.001

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Molecular Medicine

ISSN: 1528-3658