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Fig. 1 | Molecular Medicine

Fig. 1

From: PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

Fig. 1

PP121 relaxed high K+ or ACh-precontracted mTRs in a dose-dependent manner. A PP121 inhibited 80 mM K+-induced precontraction in a dose-dependent manner. B The DMSO solution (vehicle) failed to induce relaxation compared with (A). C The dose-relaxation curves of PP121 or vehicle are presented (n = 6/6 mice). D PP121 relaxed 100 µM ACh-induced precontraction in a dose-dependent manner, while vehicle could not induce relaxation under the same conditions (E). F The dose-relaxation curves of PP121 or vehicle are presented (n = 6/6 mice). G PP121 (40 µM) significantly relieved 100 µM ACh-induced bronchial cross-sectional area narrowing, while the bar graph is presented in (H) (n = 6/6 mice). *p < 0.05; **p < 0.01; ***p < 0.001

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Molecular Medicine

ISSN: 1528-3658