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Fig. 5 | Molecular Medicine

Fig. 5

From: PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

Fig. 5

PP121 relieved lung swelling and airway hyperresponsiveness in asthmatic mice. A Representative pictures of isolated lungs from the control, asthma, Dex (3 mg/kg) and PP121 groups (20 mg/kg and 50 mg/kg). B–E ACh (100 μM) induced stable contractions on mTRs isolated from the control, asthma, Dex and PP121 groups. F The bar graph shows that the 100 μM ACh-induced contractile forces in the asthma mouse model were significantly higher than those in the control, Dex and PP121 groups (n = 5/5 mice). G Gradually added ACh induced significantly higher dose-dependent contractile Rrs curves in asthma than those of the control, Dex and PP121 groups (n = 6/6 mice). *p < 0.05; **p < 0.01; ***p < 0.001

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Molecular Medicine

ISSN: 1528-3658