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Fig. 3 | Molecular Medicine

Fig. 3

From: Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina

Fig. 3

Haplodeficiency in the CAV1 gene enhances retinal thickness without triggering neurodegeneration. Representative images of PAS staining of 8-month-old retina (A). Scale bar 100 µm. Quantification of the cell number B and the thickness of GCL, INL, ONL and whole retina in central and peripheral areas respectively C in Cav-1+/+ and Cav-1+/− 8-month-old retinas. n = 5. Representative OCT images D and quantification E of whole retinal thickness of 8-month-old Cav-1+/+ and Cav-1+/− retinas. n = 4–6. GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, RPE retinal pigment epithelium. Albumin content in the retina F and G was assessed by immunoblotting. n = 4. *p < 0.05, ***p < 0.001

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Molecular Medicine

ISSN: 1528-3658