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Fig. 7 | Molecular Medicine

Fig. 7

From: Sufficient Cav-1 levels in the endothelium are critical for the maintenance of the neurovascular unit in the retina

Fig. 7

Depletion of Cav-1 decreases the endothelial expression of VEGFR2 and VE-Cadherin on the plasma membrane. Localization of VEGFR2 A and VE-Cadherin B by immunofluorescence staining in Cav-1 depleted ECs. Plasma membranes are indicated by white arrows and enlarged areas in the lower panels are labeled in the upper panels with white frames. M1 and M2 in pixel densities of line scans denote the plasma membranes for analyzing the expression of VEGFR2 C and VE-Cadherin (D). The quantification of plasma membranous and intracellular VEGFR2 E and F and VE-Cadherin G and H density are shown. I The content of Cav-1 in cell batches used for immunofluorescence staining was assessed by immunoblotting. n = 3. Scale bars 20 µm. *p < 0.05, **p < 0.01, *** < 0.001

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Molecular Medicine

ISSN: 1528-3658