Fig. 7

IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling. Schematic model: A during natural aging, the protein level of IGF2 is significantly decreased in the aged livers of old mice. B IGF2 deficiency in the liver leads to mitochondrial dysfunction, which leads to oxidative stress and cellular damage. Subsequently, oxidative stress and cellular damage are likely to activate ERK1/2 pathway and further upregulate CEBPB signaling, leading to senescence phenotypes and senescence-associated secretory phenotypes