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Fig. 2 | Molecular Medicine

Fig. 2

From: Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis

Fig. 2

Upregulated HMGB1 expression and increased macrophage infiltration in AS. A Box-plot of HMGB1 expression in the GSE28783 dataset (control = 4; AS = 4). B The size of atherosclerotic plaques at the aortic root determined by oil red O staining. C Protein levels of HMGB1 in mouse serum measured by ELISA. D HMGB1 expression in the mouse aortic root detected by RT-qPCR. E Protein expression of HMGB1 in atherosclerotic plaque tissue determined by IHC. F Expression of F4/80 in atherosclerotic plaque tissues studied by IF. G IF detection of co-localization of HMGB1 and macrophages in atherosclerotic plaque tissue (400 × , 25 μm). Red fluorescence represents the F4/80 positive Expression, while green fluorescence represents the positive Expression of HMGB1. ***Indicates p < 0.001; *indicates p < 0.05. n = 6. Data between the two groups were compared using an independent sample t-test

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Molecular Medicine

ISSN: 1528-3658