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Fig. 4 | Molecular Medicine

Fig. 4

From: Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis

Fig. 4

Macrophage-EV/siHMGB1 inhibits atherosclerotic plaque formation in mice. A HMGB1 expression in atherosclerotic plaque tissue of AS mice following macrophage-EV/siHMGB1 detected by RT-qPCR. B Expression of HMGB1 in the atherosclerotic plaque tissues of the mouse thoracic aorta assessed by IHC. C Protein content of HMGB1 in mouse serum measured by ELISA. D Atherosclerotic plaque size in the thoracic aorta determined by Oil red O staining. E Levels of inflammatory cytokines TNF-α and IL-6 in mice serum measured by ELISA. F Expression of F4/80 in atherosclerotic plaque tissue detected by IF. *Indicates p < 0.05. n = 6. Data between the two groups were compared using an independent sample t-test

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Molecular Medicine

ISSN: 1528-3658