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Fig. 7 | Molecular Medicine

Fig. 7

From: Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis

Fig. 7

Schematic diagram of the molecular mechanism of macrophage-derived EV-loaded siHMGB1 in atherosclerotic plaque formation. Macrophage-EV/siHMGB1 can inhibit HMGB1 expression in macrophages and reduce its extracellular release, and then inhibit the transformation of macrophages to foam cells, which not only inhibits the activation of Caspase-11 in macrophages but also prevents macrophage pyroptosis, thus restraining atherosclerotic plaque formation

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Molecular Medicine

ISSN: 1528-3658