Fig. 3

Glab inhibits the activation of STING and downstream signaling pathway in vivo. A–C Determination of IFN-β (A), IL-6 (B) and TNF-α (C) concentrations in collected serum by ELISA kits (n = 6 mice per group). D–F Determination of IFN-β (D), IL-6 (E) and TNF-α (F) concentrations in collected peritoneal lavage fluid by ELISA kits (n = 6 mice per group). G–I Cells were collected by centrifugation of peritoneal lavage fluid and analyzed for mRNA expression of relevant genes by qPCR assay (n = 6 mice per group). Data in (A–I) are expressed as mean ± SEM (n = 6 mice per group). one-way ANOVA and Dunnett's post hoc test were used to assess differences among groups, ^*p < 0.05, ^**p < 0.01 and ^***p < 0.001 vs. the control, NS, not significant