Fig. 2

FGF21 administration is capable of reducing lesion volume, alleviating brain edema, reducing neural apoptosis and improving neurological function after ICH. A, B T2-weighted MRI images and statistics analysis 72 h after ICH. MRI red dot area: hematoma lesion. n = 6 per group. C–E Brain water content and the TUNEL stain for each group 72 h after ICH. n = 6 per group. F–H Sensorimotor tests were performed by MNSS (F), Corner turn test (G) and Latency to fall test (H) before and after ICH. n = 12 per group. Scale bar: 50um. ^**P < 0.01 indicates ICH + Vehicle vs ICH + FGF21 by student’s t test (B), ^**P < 0.01, ^***P < 0.001 vs sham group and ^&&P < 0.01 vs ICH + Vehicle group by one-way ANOVA (C, E), ^**P < 0.01 indicates difference between two groups and ^&&P < 0.01 indicates ICH + Vehicle vs ICH + FGF21 group within a single day by two-way ANOVA (F–H). Values are presented as mean \(\pm\) SD