Fig. 8

FGF21 increases the expression of SIRT6 through the AMPK–FoxO3a pathway. A–D Western blots and statistics analysis for AMPK, p-AMPK, FoxO3a, p-FoxO3a and SIRT6 among different groups. n = 6 per group. E Schematic figure displays the mechanism of FGF21 exerts protective effects for BBB after ICH injury. FGF21 increased the level of SIRT6 through AMPK–FoxO3a pathway, further improved the mitochondrial morphology and function of ECs. ^***P < 0.001 vs Control group, ^&&P < 0.01 vs OxyHb group, ^#P < 0.05, ^##P < 0.01 vs OxyHb + FGF21 group by one-way ANOVA (B–D). ns: no significant. Values are presented as mean \(\pm\) SD