Fig. 6

Effect of metformin on alleviating nasal inflammation and symptoms and anxiety and depression-like behaviors in AR mice. A Schematic timeline of the experimental procedure. B Representative travel tracing in elevated cross maze test from mice. C Total time of open and closed entries. D Percent of open arms entries. E Percent of open arms times. F Head-dipping times. G Representative travel tracing in open field test from mice. H Total movement distance of mice. I Central entry times of mice. J Central durations of mice. K The first immobility time on tail suspension test. L Immobility time in the last 4 min on tail suspension test. M Average time of struggling behavior, swimming behavior, and floating behavior on the forced swim test. N Immobility time in the last 4 min on the forced swim test. O The sucrose preference (%) of sucrose preference test. (*P < 0.05, **P < 0.01, ***P < 0.001)