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Fig. 5 | Molecular Medicine

Fig. 5

From: Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway

Fig. 5

NETs expression, intracellular ROS level, and energy metabolism in neutrophils under the treatment of CsA. A Immunofluorescence and ratio of fluorescence intensity of Sytox green to Hoechst 33342 in neutrophils stimulated by LPS at the presence of CsA; Green: Sytox green, Blue: Hoechst 33342 (**P < 0.01 for Ctrl vs neutrophils stimulated by LPS, ****P < 0.0001 for neutrophils stimulated by LPS without CsA vs with CsA). B, C Intracellular energy metabolites in neutrophils stimulated by LPS at the presence of CsA (*P < 0.05, **P < 0.01). D NADPH/NADP + in neutrophils stimulated by LPS at the presence of CsA (*P < 0.05). E Change of intracellular ROS level in neutrophils stimulated by LPS at the presence of CsA for 1 h (*P < 0.05, **P < 0.01, ***P < 0.001 for LPS vs LPS + CsA)

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Molecular Medicine

ISSN: 1528-3658