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Fig. 6 | Molecular Medicine

Fig. 6

From: Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway

Fig. 6

The influence of CsA on NETs expression dependent on G6PD. A The activity and transcriptional level of G6PD in neutrophils from UC patients and HC (ns: not significance, **P < 0.01). B The activity and transcriptional level of G6PD in neutrophils treated with LPS with or without CsA (ns: not significance, **P < 0.01). C Immunofluorescence and ratio of fluorescence intensity of Sytox green to Hoechst 33342 in neutrophils stimulated by LPS at the presence of 6-AN; Green: Sytox green, Blue: Hoechst 33342 (****P < 0.0001 for neutrophils treated with LPS vs LPS + 6-AN). D Change of intracellular ROS level in neutrophils stimulated by LPS in the presence of 6-AN for 1 h (ns: not significance, ****P < 0.0001 for neutrophils treated with LPS vs LPS + 6-AN)

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Molecular Medicine

ISSN: 1528-3658