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Fig. 7 | Molecular Medicine

Fig. 7

From: Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway

Fig. 7

The decrease of G6PD activity but not protein level dependent on activation of P53 protein by CsA. A Volcano map and cluster heat map of differentially expressed genes in LPS and LPS + CsA groups (|log2FC|≥ 1.5, Qvalue ≤ 0.05). B Protein interaction between differentially expressed genes and G6PD and their cluster heat map. C TP53 transcription levels in the two groups (**P < 0.01 for neutrophils treated with LPS vs LPS + CsA). D Western blotting and quantification of the expression of P53 protein level in each group (*P < 0.05 for neutrophils treated with LPS vs LPS + CsA). E The activity of G6PD in neutrophils under the treatment of PFT-α for 3 h (***P < 0.001 for neutrophils treated with LPS + CsA vs LPS and LPS + CsA + PFT-α). F Western blotting and quantification of the expression of P53 and G6PD protein level in each group (ns: not significance; **P < 0.01 for neutrophils treated with LPS + CsA vs LPS + CsA + PFT-α; ***P < 0.001 for neutrophils treated with LPS vs LPS + CsA)

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Molecular Medicine

ISSN: 1528-3658