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Fig. 7 | Molecular Medicine

Fig. 7

From: Sustained activation of 12/15 lipoxygenase (12/15 LOX) contributes to impaired renal recovery post ischemic injury in male SHR compared to females

Fig. 7

Blocking 12/15 LOX activation attenuates macrophage infiltration 7 days post-IR in male SHR. Renal macrophage infiltration was assessed by immunohistochemical analysis of CD68 staining in kidney samples collected 7 days post-IR in a blinded manner. Brown nuclei staining indicates macrophage CD68 positive cells. Representative images are provided in Panel A for males and Panel C for females with the respective quantification in Panels B & D. Data are expressed as mean ± SEM; n = 5–6 rats in each group with individual animal data indicated by the symbols. Filled symbols indicate vehicle or ML355 treated sham animals, open symbols indicate vehicle or ML355-treated IR animals, males are represented by squares and upward triangle and females by circles and downward triangle. Data were compared via 2-way ANOVA with P < 0.05 considered significant

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Molecular Medicine

ISSN: 1528-3658