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Fig. 2 | Molecular Medicine

Fig. 2

From: G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis

Fig. 2

GPER1 protected NSCLC cells from ferroptosis. (A, B) Heatmap showing that GPER1 reduced sensitivity to the ferroptosis inducers RSL3 and Erastin. Darker blue indicates higher cell viability, and darker red indicates worse viability. The number at the bottom of the heatmap indicates the concentration of G1. (C) Representative phase-contrast images and viability staining (green indicates live cells, and red indicates dead cells) of A549 and H1299 cells treated with G1, RSL3, or Erastin. (D) The fluorescence of BODIPY 581/591C11 in A549 and H1299 cells treated with G1, RSL3, or Erastin, was determined using flow cytometry. (E) MDA levels in A549 and H1299 cells treated with G1, RSL3, or Erastin. The results are presented as the mean ± SD. n = 3; *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658