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Fig. 6 | Molecular Medicine

Fig. 6

From: G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis

Fig. 6

GPER1 correlated with SCD1 in NSCLC tissues. (A) An immunofluorescence assay was performed on GPER1 (Green, TYR-520), SCD1 (Purple, TYR-690), SREBP1 (Red, TYR-570) and nucleus (Blue, PADI) in the NSCLC tissue with different levels of GPER1 expression (the right panel shows higher levels and the left one shows lower levels). (B, C) The expression of GPER1 and SCD1 in tumor tissue and normal tissue were detected using immunohistochemistry. (D) The relationship between GPER1 and SCD1 expression in NSCLC tissue; R squared: 0.1556. (E) Overall survival (OS) and progression-free survival (PFS) of NSCLC cells with GPER1 expression. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658