Fig. 2
Effects of Stx17 on pathological and synapse-related protein expression after Meth exposure. (A) Intracellular Aβ1−42 in the mouse hippocampus was measured by ELISAs. Data are shown as the mean ± SEM (n = 3). *p < 0.05 compared with the control group; #p < 0.05 compared to the Meth group. (B, C) Hippocampal CA1, CA3 and DG stained with anti-p-tau (s124) antibody (red) and DAPI (blue), scale bar = 50 μm. (D-F) The levels of Drebrin and PSD95 in the hippocampus were assessed by western blotting after Meth exposure and Stx17 overexpression. Data are shown as the mean ± SEM (n = 3). *p < 0.05 compared with the control group; ##p < 0.01 compared to the Meth group. (G-J) Hippocampal CA1, CA3, and DG regions stained with anti-Drebrin antibody (red), anti-PSD95 antibody (red), and DAPI (blue); scale bar = 50 μm. Data are shown as the mean ± SEM (n = 3). ***p < 0.001 and ****p < 0.0001 compared with the control group; #p < 0.05 and ##p < 0.01 compared to the Meth group