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Fig. 3 | Molecular Medicine

Fig. 3

From: Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice

Fig. 3

Stx17 overexpression in the hippocampus alleviates autophagic defects. (A-E) p62, LC3II/I, Rab5, and Rab7 levels in the hippocampus were determined by Western blotting after Meth exposure and Stx17 overexpression in mice. Data are shown as the mean ± SEM (n = 3). *p < 0.05 and **p < 0.01 compared with the control group; #p < 0.05 and ##p < 0.01 compared to the Meth group. (F) Autophagy-related membrane structures were observed in the hippocampus in Meth-exposed and Stx17-overexpressing mouse brains by transmission electron microscopy. * and red arrows represent autophagosomes with double- or multilayer membrane structures, and # stands for autophagolysosomes with a monolayer membrane structure. Scale bar = 5 μm

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Molecular Medicine

ISSN: 1528-3658