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Fig. 4 | Molecular Medicine

Fig. 4

From: Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice

Fig. 4

Time course expression of autophagy-related proteins and EGFR accumulation in early endosomes and autophagosomes after Meth exposure in primary hippocampal neurons. (A-F) After Meth exposure at different doses, the levels of p62, Stx17, Rab5, Rab7, and LC3II/I were assessed by Western blot analysis in primary hippocampal neurons. Data are shown as the mean ± SEM (n = 3). (G-H) EGF receptor trafficking assay. After Meth exposure, primary hippocampal neurons were costained with anti-EGFR (green), anti-Rab5 (red), or anti-LC3 (red) antibodies and observed by immunofluorescence, along with a statistical graph. Scale bar = 5 μm

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Molecular Medicine

ISSN: 1528-3658