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Fig. 8 | Molecular Medicine

Fig. 8

From: Key roles of autophagosome/endosome maturation mediated by Syntaxin17 in methamphetamine-induced neuronal damage in mice

Fig. 8

Meth-induced inhibition of autophagosome and endosome maturation mechanism schematic. Stx17 overexpression promotes CCZ1 activation of Rab7, facilitating late endosome formation and decreasing the overlap between ATG5 and LC3, promoting autophagosome maturation. These processes initiate upstream autophagosome-late endosome/lysosome fusion, alleviate Meth-induced autophagic dysfunction, and ameliorate memory impairment and neuropathology

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Molecular Medicine

ISSN: 1528-3658