Fig. 3
A literature-based logic model of mucosal-immune system interactions. Nodes: Yellow, distinct immune cell types; Green, immune signaling molecules; Red, environmental pathogens. Edges: Red, inhibition; Green, stimulation. Conditionals: Cyan, Naïve T Cell dependent stimulation; Blue, Mucus layer dependent stimulation. GM-CSF—granulocyte–macrophage colony-stimulating factor; IFNg–interferon γ; IL–interleukin; ROI–reactive oxygen intermediary; NK–natural killer cells; CCL2/MCP1—chemokine ligand 2/monocyte chemoattractant protein 1; TGFB–transforming growth factor β; Th–T helper cell; TNFa–tumor necrosis factor α; Treg–T regulator cell