Fig. 3
From: TIM-3 regulates the proliferation by BDNF-mediated PI3K/AKT axis in the process of endometriosis
Effects of TIM-3 downregulation and overexpression on cell proliferation and apoptosis. (A, B) Downregulation of TIM-3 inhibited cell proliferation of hESCs, detected by CCK8 and clone-forming assay, and overexpression did the opposite effect. (C, D) TIM-3 affected in the clone-forming ability of hESCs. (E, F) Downregulation of TIM-3 inhibited cell proliferation of ESCs, detected by EDU assay. Overexpression of TIM-3 promoted cell proliferation of ESCs. (G, H) TIM-3 knockdown promoted the apoptosis, and TIM-3 overexpression inhibited ESCs apoptosis. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001)