Fig. 2

Administration of BAK resulted in the upregulation of prominent inflammatory responses in the cornea by RNA-seq analysis. A PCA and B correlation plots showed a clear genetic distinction between the corneas in normal animals and untreated BAK-injured animals. C Enrichment map generated through GSEA analysis and arranged based on GO pathways. It was observed that the corneal injury involved mainly adaptive immune response, immune cell migration, and cytokine production. All bioinformatics analyzes were performed with n = 3 samples per group