Fig. 3

UCS and UCPRP notably improved the morphology and pathological changes of the ocular surface following the BAK insult in mice. A Representative close-up images of the BAK-injured mice cornea showing the recovery in opacity and fluorescein sodium staining pattern over time after UCS and UCPRP treatment. B and C are the respective scoring graphs; n = 7 cornea measurements per group. Additionally, the D tear production; n = 7 cornea measurements per group, E tear break-up time; n = 7 cornea measurements per group, F corneal sensitivity; n = 7 cornea measurements per group, G tear Muc5ac levels; n = 3 experimental repeats, displayed marked restoration that was close to pre-injury levels. These results also corresponded to a H significant downregulation of Il1b and Tnfa at Day 10 post treatment; n = 3 experimental repeats. *p < 0.05, **p < 0.01, ***p < 0.001. All data were presented as mean ± SD