Fig. 1

A Schematic of experimental paradigm. B Representative color plot in a mouse hippocampus depicting serotonin oxidation in an animal after MPTP. Vertical line shows the CV overlaid in the right-hand corner. Horizontal line shows the concentration vs. time (IT) curves presented in D. C Representative images of tyrosine hydroxylase immunostaining in male (top images) and female (bottom images) mice administered either with saline vehicle (left images) or MPTP (right images). Scale bar is 250 µm in length. D Concentration vs. time curve (average ± SEM) comparing mice administered MPTP (n = 22, 13 male and 9 female) vs. mice administered saline (n = 15, 5 male and 10 female). Male is shown in green while females are shown in purple. E Comparison of max amplitudes and serotonin reuptake decay constant (average ± SEM) of FSCV curves presented in D. F Comparison of test scores between control mice (blue) and MPTP-treated mice (red) (tail suspension test: n = 14 control, n = 18 MPTP-treated; open field test: n = 10 control, n = 12 MPTP-treated; elevated zero maze test, n = 17 control, n = 22 MPTP-treated)