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Fig. 7 | Molecular Medicine

Fig. 7

From: A new physiological medium uncovers biochemical and cellular alterations in Lesch-Nyhan disease fibroblasts

Fig. 7

LND fibroblasts express higher levels of the folate carrier SLC19A1. Control and LND fibroblasts were cultured in Plasmax-PV containing different levels of FA. Total RNA was extracted and SLC19A1 mRNA levels quantified by qRT-PCR as described in Material and Methods. Results were expressed in arbitrary units (AU), using control fibroblasts maintained with 2200 nM FA as a reference condition for normalization of the data. The results are the mean ± SEM of 3 controls and 4 LND patients. *P < 0.05. Two-way ANOVA, Fisher’s multiple comparison test

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Molecular Medicine

ISSN: 1528-3658