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Fig. 3 | Molecular Medicine

Fig. 3

From: Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression

Fig. 3

KDM5C/PFDN5 regulates viability of CRC cells and affects c-Myc signal transduction. A RT-qPCR to analyze the expression of KDM5C and PFDN5 in HCT116 and SW480 cells after shRNA transfection examined by (two-way ANOVA); B CCK-8 assay to analyze the proliferation of the cells examined by the (two-way ANOVA); C, D Transwell assays to analyze migration C and invasion abilities D of HCT116 and SW480 cells (two-way ANOVA); E dual luciferase assay to examine the transcriptional activity of c-Myc in the HCT116 and SW480 cells (two-way ANOVA). Three biological replicates were performed. *p < 0.05 vs. the sh-NC group; #p < 0.05 vs. the sh-KDM5C group

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Molecular Medicine

ISSN: 1528-3658