Fig. 7From: Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progressionGraphical abstract. KDM5C is highly expressed in CRC. It catalyzes demethylation of H3K4me3 on the PFDN5 promoter, therefore suppressing PFDN5 transcription and leading to transcriptional activation of protooncogene c-Myc. This results in cell autophagy repression and CRC progressionBack to article page