Fig. 5

SI inhibits the growth of tumor xenografts in mice. A The morphology of the mouse model and separated tumor xenografts; B the tumor weight on the 28th day; C the tumor volumes every 4 days; D the apoptotic cells were detected by TUNEL staining; E the active cells were detected by IHC of Ki67; F HE staining for lung tissues; G the protein expression of P62, LC3 II/I, PINK1, and parkin (autophagy-related proteins) were detected by western blot. OS model mice were gavaged with 40 mg/kg SI once a day for 28 days. Experiments were performed with five mice per group; statistical analysis was performed using an independent t-test. ^**P < 0.01