Fig. 2
Aged mice exhibited bone loss and deterioration of bone microstructure. A Representative micro-CT images of the distal femur from young (3-month-old) mice and old (18-month-old) mice. B–H Quantitative parameters in the distal femur, including bone mineral density (BMD), bone volume fraction (BV/TV), trabecular thickness (Tb/Vt.Th), trabecular number (Tb/Vt.N), trabecular separation (Tb/Vt.Sp), cortical bone thickness (Ct.th) and average cortical bone area (Ct.BArea). (I) Representative μCT images of L4 vertebral bodies. J–N Quantitative parameters in L4 vertebral bodies. Data represent mean ± S.D. of at least three independent experiments (n = 6 per group). ***p < 0.001; ****p < 0.0001