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Fig. 2 | Molecular Medicine

Fig. 2

From: α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

Fig. 2

AKG alleviates myocardial hypertrophy and fibrosis in TAC mice. Whole (A, scale = 2 mm) and local (B, scale = 50 μm) heart tissue sections with HE staining. (C) The left ventricles tissue sections with WGA staining (scale = 50 μm). (D) The left ventricles tissue sections with Masson staining (scale = 50 μm). (E) The statistical data of HW/BW and HW/TL in each group. (F) Quantitative analysis of the cross sectional area of cardiomyocytes in panel C. (G) Quantitative analysis of myocardial fibrosis in panel D. ***P < 0.001 vs. Sham group; ##P < 0.01, ###P < 0.001 vs. TAC group

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Molecular Medicine

ISSN: 1528-3658