Skip to main content
Fig. 3 | Molecular Medicine

Fig. 3

From: α-Ketoglutarate improves cardiac insufficiency through NAD+-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice

Fig. 3

Myocardial metabolomics analysis. (A) Heatmap showing the total analysis of cardiac metabolites. (B) Principal component analysis of cardiac metabolites. (C) Partial least squares discriminant analysis of cardiac metabolites. (D) Relative quantitative analysis of α-ketoglutaric acid-related metabolites. (E) Venn Diagram comparing the significantly changed metabolites after TAC surgery and AKG treatment (F) Volcanic analysis of metabolites in the Sham group and TAC group, and in the TAC group and TAC + AKG group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. Sham group; #P < 0.05, ###P < 0.001 vs. TAC group

Back to article page

Molecular Medicine

ISSN: 1528-3658